Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis.
J Trace Elem Med Biol
; 55: 58-63, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31345366
ABSTRACT
BACKGROUND:
Alzheimer's disease (AD) is the most common age-related neurodegenerative disease. An altered homeostasis of Zinc (Zn) and Copper (Cu), as well as a dysregulated expression of Zn-regulatory proteins have been previously described in AD. Acetylcholinesterase inhibitors (AChEI) are commonly used as AD treatment to improve cognitive function, but their effect on Zn homeostasis is still unexplored.OBJECTIVES:
The aims of this study were to define the metal dyshomeostasis in AD patients, to investigate AChEI influence on Zn homeostasis and inflammation, and to analyze the relationship between cognitive impairment at two-year follow-up and metal concentrations, considering AChEI use. METHODS ANDRESULTS:
84 Healthy Elderly (HE) and 95 AD patients were enrolled (62 AchEI user and 33 AchEI naïve). HE showed similar plasma Zn and Cu concentrations and Cu/Zn ratio in comparison to AChEI users, but significantly higher Zn level, as well as lower Cu amount and Cu/Zn ratio than AChEI naïve patients. Moreover, AChEI users had increased Zn plasma level, reduced Cu amount, Cu/Zn ratio, and IL1ß concentration and lower Zip2 lymphocytic expression vs. naïve patients. A multiple linear regression analysis showed that the MMSE score decline after two-year follow-up was reduced by AChEI therapy and was positively associated with plasma Zn decrease over time.CONCLUSION:
Our data revealed that AChEI use may affect peripheral Zn and Cu homeostasis in AD patients, decrease Cu/Zn ratio demonstrating a general reduction of inflammatory status in patients under AChEI treatment. Finally, AChEI influence on circulating Zn could be implicated in the drug-related slowdown of cognitive decline.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Acetilcolinesterasa
/
Zinc
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Inhibidores de la Colinesterasa
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Cobre
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Enfermedad de Alzheimer
/
Homeostasis
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Trace Elem Med Biol
Asunto de la revista:
METABOLISMO
/
SAUDE AMBIENTAL
Año:
2019
Tipo del documento:
Article