Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a ß-N-acetylhexosaminidase in Akkermansia muciniphila.

Chen, Xi; Li, Mengyu; Wang, Yongzhong; Tang, Rupei; Zhang, Min

Chen, Xi; Li, Mengyu; Wang, Yongzhong; Tang, Rupei; Zhang, Min.

Afiliación

Chen X; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institute, Anhui University, 111 Jiulong Road, Hefei, Anhui, China.
Li M; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institute, Anhui University, 111 Jiulong Road, Hefei, Anhui, China.
Wang Y; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institute, Anhui University, 111 Jiulong Road, Hefei, Anhui, China.
Tang R; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui, China.
Zhang M; School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei, Anhui, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institute, Anhui University, 111 Jiulong Road, Hefei, Anhui, China. Electronic address: zhmin07@ahu.edu.cn.

Biochem Biophys Res Commun ; 517(1): 29-35, 2019 09 10.

Article en En | MEDLINE | ID: mdl-31345574

Asunto(s)

Proteínas Bacterianas/metabolismo; Verrucomicrobia/metabolismo; beta-N-Acetilhexosaminidasas/metabolismo; Akkermansia; Proteínas Bacterianas/química; Biocatálisis; Dominio Catalítico; Cristalografía por Rayos X; Cinética; Modelos Moleculares; Conformación Proteica; Especificidad por Sustrato; Verrucomicrobia/química; beta-N-Acetilhexosaminidasas/química

Palabras clave

Akkermansia muciniphila; Catalytic mechanism; Crystallographic evidence; ß-N-Acetylhexosaminidase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-N-Acetilhexosaminidasas / Verrucomicrobia Tipo de estudio: Prognostic_studies Idioma: En Revista: Biochem Biophys Res Commun Año: 2019 Tipo del documento: Article País de afiliación: China

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