Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.

Zhou, Du-Chao; Lu, Yu-Ting; Mai, Yan-Wen; Zhang, Chen; Xia, Jie; Yao, Pei-Fen; Wang, Hong-Gen; Huang, Shi-Liang; Huang, Zhi-Shu

Zhou, Du-Chao; Lu, Yu-Ting; Mai, Yan-Wen; Zhang, Chen; Xia, Jie; Yao, Pei-Fen; Wang, Hong-Gen; Huang, Shi-Liang; Huang, Zhi-Shu.

Afiliación

Zhou DC; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Lu YT; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Mai YW; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhang C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xia J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Yao PF; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Wang HG; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Huang SL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: lsshsl@mail.sysu.edu.cn.
Huang ZS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.

Bioorg Chem ; 91: 103131, 2019 10.

Article en En | MEDLINE | ID: mdl-31377387

Asunto(s)

Antineoplásicos/farmacología; Quinazolinas/farmacología; Quinonas/farmacología; Inhibidores de Topoisomerasa II/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/metabolismo; Apoptosis/efectos de los fármacos; Sitios de Unión; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; ADN-Topoisomerasas de Tipo II/química; ADN-Topoisomerasas de Tipo II/metabolismo; Diseño de Fármacos; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Simulación del Acoplamiento Molecular; Estructura Molecular; Unión Proteica; Quinazolinas/síntesis química; Quinazolinas/metabolismo; Quinonas/síntesis química; Quinonas/metabolismo; Relación Estructura-Actividad; Inhibidores de Topoisomerasa II/síntesis química; Inhibidores de Topoisomerasa II/metabolismo

Palabras clave

Anti-proliferation; Apoptosis; Catalytic inhibitor; Mansonone; Perimidine o-quinone; Topoisomerase II

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Quinonas / Inhibidores de Topoisomerasa II / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article

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