Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli.
Chem Commun (Camb)
; 55(68): 10158-10161, 2019 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-31389420
ABSTRACT
We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Celulosa
/
Escherichia coli K12
/
Nanofibras
/
Mananos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia