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Discovery of ß-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Pinkerton, Anthony B; Peddibhotla, Satyamaheshwar; Yamamoto, Fusayo; Slosky, Lauren M; Bai, Yushi; Maloney, Patrick; Hershberger, Paul; Hedrick, Michael P; Falter, Bekhi; Ardecky, Robert J; Smith, Layton H; Chung, Thomas D Y; Jackson, Michael R; Caron, Marc G; Barak, Lawrence S.
Afiliación
  • Pinkerton AB; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Peddibhotla S; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Yamamoto F; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Slosky LM; Duke University Medical Center , Durham , North Carolina 27709 , United States.
  • Bai Y; Duke University Medical Center , Durham , North Carolina 27709 , United States.
  • Maloney P; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Hershberger P; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Hedrick MP; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Falter B; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Ardecky RJ; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Smith LH; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Chung TDY; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Jackson MR; Conrad Prebys Center for Chemical Genomics , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , California 92037 , United States.
  • Caron MG; Duke University Medical Center , Durham , North Carolina 27709 , United States.
  • Barak LS; Duke University Medical Center , Durham , North Carolina 27709 , United States.
J Med Chem ; 62(17): 8357-8363, 2019 09 12.
Article en En | MEDLINE | ID: mdl-31390201
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Enfermedades del Sistema Nervioso Central / Receptores de Neurotensina / Descubrimiento de Drogas / Beta-Arrestinas Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Enfermedades del Sistema Nervioso Central / Receptores de Neurotensina / Descubrimiento de Drogas / Beta-Arrestinas Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos