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Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity.
Song, Pei-Lu; Wang, Gang; Su, Yuan; Wang, Han-Xun; Wang, Jian; Li, Feng; Cheng, Mao-Sheng.
Afiliación
  • Song PL; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang G; Center for Drug Evaluation, National Medical Products Administration, Beijing 100022, China.
  • Su Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang HX; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: jianwang@syphu.edu.cn.
  • Li F; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China. Electronic address: fli@mail.cmu.edu.cn.
  • Cheng MS; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: mscheng@syphu.edu.cn.
Bioorg Chem ; 91: 103168, 2019 10.
Article en En | MEDLINE | ID: mdl-31400553
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Neoplasias Gástricas / Inhibidores de Proteínas Quinasas / Quinasas p21 Activadas / Descubrimiento de Drogas / Antineoplásicos Tipo de estudio: Evaluation_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Neoplasias Gástricas / Inhibidores de Proteínas Quinasas / Quinasas p21 Activadas / Descubrimiento de Drogas / Antineoplásicos Tipo de estudio: Evaluation_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: China