A Flexible Acetylcholinesterase-Modified Graphene for Chiral Pesticide Sensor.
J Am Chem Soc
; 141(37): 14643-14649, 2019 09 18.
Article
en En
| MEDLINE
| ID: mdl-31448915
ABSTRACT
Sensors based on graphene are promising devices for chemical and biological detection owing to their high sensitivity, biocompatibility, and low costs. However, for chiral recognition, which is very important in biological systems, graphene sensors remain unable to discriminate enantiomers. Here, using chiral pesticide molecules as an example, we realized a highly sensitive graphene chiral sensor by modification with acetylcholinesterase (AChE). Quantum chemical simulations indicate that the inhibition effect of the enantiomer on AChE was transferred to graphene, which allowed for the electrical detection of chiral molecules. Under an operating voltage of 1 V, the sensitivity of the device reached 0.34 µg/L and 0.32 µg/L for (+)/(-)-methamidophos, respectively, which is much higher than by circular dichroism (6.90 mg/L and 5.16 mg/L, respectively). Furthermore, real-time, rapid detection was realized by combining with smartphones and wireless transmission.
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1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organotiofosforados
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Plaguicidas
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Acetilcolinesterasa
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Grafito
Idioma:
En
Revista:
J Am Chem Soc
Año:
2019
Tipo del documento:
Article