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A Flexible Acetylcholinesterase-Modified Graphene for Chiral Pesticide Sensor.
Zhang, Yunpeng; Liu, Xiaotong; Qiu, Shi; Zhang, Qiuqi; Tang, Wei; Liu, Hongtao; Guo, Yunlong; Ma, Yongqiang; Guo, Xiaojun; Liu, Yunqi.
Afiliación
  • Zhang Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , PR China.
  • Liu X; College of Science , China Agricultural University , Beijing 100193 , PR China.
  • Qiu S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , PR China.
  • Zhang Q; College of Science , China Agricultural University , Beijing 100193 , PR China.
  • Tang W; Department of Electronic Engineering, School of Electronic Information and Electrical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , PR China.
  • Liu H; Department of Electronic Engineering, School of Electronic Information and Electrical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , PR China.
  • Guo Y; Department of Electronic Engineering, School of Electronic Information and Electrical Engineering , Shanghai Jiao Tong University , Shanghai 200240 , PR China.
  • Ma Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , PR China.
  • Guo X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , PR China.
  • Liu Y; College of Science , China Agricultural University , Beijing 100193 , PR China.
J Am Chem Soc ; 141(37): 14643-14649, 2019 09 18.
Article en En | MEDLINE | ID: mdl-31448915
ABSTRACT
Sensors based on graphene are promising devices for chemical and biological detection owing to their high sensitivity, biocompatibility, and low costs. However, for chiral recognition, which is very important in biological systems, graphene sensors remain unable to discriminate enantiomers. Here, using chiral pesticide molecules as an example, we realized a highly sensitive graphene chiral sensor by modification with acetylcholinesterase (AChE). Quantum chemical simulations indicate that the inhibition effect of the enantiomer on AChE was transferred to graphene, which allowed for the electrical detection of chiral molecules. Under an operating voltage of 1 V, the sensitivity of the device reached 0.34 µg/L and 0.32 µg/L for (+)/(-)-methamidophos, respectively, which is much higher than by circular dichroism (6.90 mg/L and 5.16 mg/L, respectively). Furthermore, real-time, rapid detection was realized by combining with smartphones and wireless transmission.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Organotiofosforados / Plaguicidas / Acetilcolinesterasa / Grafito Idioma: En Revista: J Am Chem Soc Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Organotiofosforados / Plaguicidas / Acetilcolinesterasa / Grafito Idioma: En Revista: J Am Chem Soc Año: 2019 Tipo del documento: Article