Your browser doesn't support javascript.
loading
Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells.
Zhang, Junshuai; Hu, Jiyong; Peng, Kun; Song, Wei; Zhi, Shuangcheng; Yang, Endian; Zhao, Jin'an; Hou, Hongwei.
Afiliación
  • Zhang J; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
  • Hu J; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
  • Peng K; Institute of Inorganic Chemistry, University of Wuerzburg, Bavaria 97074, Germany.
  • Song W; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
  • Zhi S; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
  • Yang E; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
  • Zhao J; College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China and College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. zjinan@zzu.edu.cn.
  • Hou H; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. zjinan@zzu.edu.cn.
Chem Commun (Camb) ; 55(79): 11944-11947, 2019 Oct 01.
Article en En | MEDLINE | ID: mdl-31531457
A novel hexanuclear copper(ii)-based complex, [Cu6(tpbb)2(NO3)12] (1), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apoptosis / Carcinoma Hepatocelular / Cobre / Complejos de Coordinación / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apoptosis / Carcinoma Hepatocelular / Cobre / Complejos de Coordinación / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article