Synthesis of high payload nanohydrogels for the ecapsulation of hydrophilic molecules via inverse miniemulsion polymerization: caffeine as a case study.
Drug Dev Ind Pharm
; 45(12): 1862-1870, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31549528
ABSTRACT
The association of an active principle with a nanocarrier is known to improve its stability and protect it from external factors. Nevertheless, loading of nanoparticles with highly hydrophilic substances like caffeine remains a tricky issue. In the present study, inverse miniemulsion systems were successfully coupled to UV radiation to synthesize polymeric nanohydrogels for drug delivery. The proper choice of the continuous and dispersed phase chemical composition led to the entrapment of active principle into the miniemulsion droplets. Our confinement-based strategy enabled unprecedented caffeine encapsulation efficiency inside 100-nm particles. Dimensional, thermal, and spectroscopic characterizations were carried out to investigate both unloaded and loaded nanohydrogels. Furthermore, in vitro release studies evaluated caffeine release kinetics from nanohydrogels by means of dialysis tests. It was demonstrated that controlled and sustained release occurred within the first 50 hours. Experimental data were found to fit the Higuchi model suggesting that the active principle release is diffusion controlled.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cafeína
/
Portadores de Fármacos
/
Hidrogeles
/
Composición de Medicamentos
/
Nanopartículas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Drug Dev Ind Pharm
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia