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Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action.
Karton-Lifshin, Naama; Katalan, Shahaf; Columbus, Ishay; Chen, Ravit; Yehezkel, Lea; Madmon, Moran; Dagan, Shai; Elias, Shlomi; Fridkin, Gil; Zafrani, Yossi.
Afiliación
  • Karton-Lifshin N; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Katalan S; Pharmacology, Israel Institute for Biological Research, Ness-Ziona 74000, Israel.
  • Columbus I; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Chen R; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Yehezkel L; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Madmon M; Analytical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel.
  • Dagan S; Analytical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel.
  • Elias S; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Fridkin G; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
  • Zafrani Y; Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel. naamal@iibr.gov.il gilf@iibr.gov.il yossiz@iibr.gov.il.
Chem Commun (Camb) ; 55(83): 12471-12474, 2019 Oct 25.
Article en En | MEDLINE | ID: mdl-31566634
The ability of mono N-methyl-1,4-diazabicyclo[2.2.2]octane fluoride (Me-DABCOF, 1) to act as a bifunctional reagent that effectively and universally neutralizes both the persistent and extremely toxic blister agent HD and the nerve agent VX in nearly neutral aqueous solution, alumina powder or a hydrogel formulation, is described.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article