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A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.
Hart, Elizabeth M; Mitchell, Angela M; Konovalova, Anna; Grabowicz, Marcin; Sheng, Jessica; Han, Xiaoqing; Rodriguez-Rivera, Frances P; Schwaid, Adam G; Malinverni, Juliana C; Balibar, Carl J; Bodea, Smaranda; Si, Qian; Wang, Hao; Homsher, Michelle F; Painter, Ronald E; Ogawa, Anthony K; Sutterlin, Holly; Roemer, Terry; Black, Todd A; Rothman, Deborah M; Walker, Scott S; Silhavy, Thomas J.
Afiliación
  • Hart EM; Department of Molecular Biology, Princeton University, Princeton, NJ 08540.
  • Mitchell AM; Department of Molecular Biology, Princeton University, Princeton, NJ 08540.
  • Konovalova A; Department of Molecular Biology, Princeton University, Princeton, NJ 08540.
  • Grabowicz M; Department of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.
  • Sheng J; Department of Molecular Biology, Princeton University, Princeton, NJ 08540.
  • Han X; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA 30322.
  • Rodriguez-Rivera FP; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
  • Schwaid AG; Division of Infectious Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322.
  • Malinverni JC; Department of Molecular Biology, Princeton University, Princeton, NJ 08540.
  • Balibar CJ; Chemical Biology, Merck & Co., Inc., Kenilworth, NJ 07033.
  • Bodea S; Chemical Biology, Merck & Co., Inc., Kenilworth, NJ 07033.
  • Si Q; Chemistry, Merck & Co., Inc., Boston, MA 02115.
  • Wang H; Infectious Disease, Merck & Co., Inc., West Point, PA 19486.
  • Homsher MF; Infectious Disease, Merck & Co., Inc., West Point, PA 19486.
  • Painter RE; Chemistry, Merck & Co., Inc., Boston, MA 02115.
  • Ogawa AK; Pharmacology, Merck & Co., Inc., West Point, PA 19486.
  • Sutterlin H; Infectious Disease, Merck & Co., Inc., West Point, PA 19486.
  • Roemer T; Biologics and Vaccine Analytics, Merck & Co., Inc., West Point, PA 19486.
  • Black TA; Pharmacology, Merck & Co., Inc., West Point, PA 19486.
  • Rothman DM; Chemistry, Merck & Co., Inc., South San Francisco, CA 94080.
  • Walker SS; Biology, Prokaryotics, Inc., Union, NJ 07083.
  • Silhavy TJ; Biology, Prokaryotics, Inc., Union, NJ 07083.
Proc Natl Acad Sci U S A ; 116(43): 21748-21757, 2019 10 22.
Article en En | MEDLINE | ID: mdl-31591200

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de la Membrana Bacteriana Externa / Triazinas / Proteínas de Escherichia coli / Escherichia coli / Multimerización de Proteína / Antibacterianos Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de la Membrana Bacteriana Externa / Triazinas / Proteínas de Escherichia coli / Escherichia coli / Multimerización de Proteína / Antibacterianos Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article