Correlates of therapeutic efficacy in experimental methicillin-resistant Staphylococcus aureus endocarditis.
Chemotherapy
; 34(1): 46-55, 1988.
Article
en En
| MEDLINE
| ID: mdl-3162413
ABSTRACT
Seventy animals with experimental aortic valve endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA) were randomized to receive no therapy; pefloxacin 40 or 80 mg/kg/day i.v.; or vancomycin 30 mg/kg/day i.v. Vancomycin caused a more rapid decrease in intravegetation MRSA counts than pefloxacin at 40 or 80 mg/kg/day (p less than 0.001, p less than 0.05, respectively, therapy day 3). The major correlate of therapeutic efficacy in this study was the significantly higher mean intravegetation levels achieved by vancomycin (16.8 +/- 6.1 micrograms/g) versus those attained by pefloxacin therapy at either 40 (1.6 +/- 0.13 micrograms/g) or 80 mg/kg/day (2.8 +/- 0.53 micrograms/g, p less than 0.005, p less than 0.025, respectively).
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Vancomicina
/
Norfloxacino
/
Endocarditis Bacteriana
/
Meticilina
/
Antiinfecciosos
Límite:
Animals
Idioma:
En
Revista:
Chemotherapy
Año:
1988
Tipo del documento:
Article