Dapsone-induced hepatic complications: it's time to think beyond methemoglobinemia.
Drug Chem Toxicol
; 44(3): 330-333, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-31631707
ABSTRACT
Drug-induced liver injury is an important cause of hepatotoxicity and poses a challenging clinical problem with respect to both diagnosis and management. Patients susceptible to hepatotoxicity on exposure to dapsone is constantly on the rise. Dapsone (4,4'-diaminodiphenylsulfone) is clinically used alone or in combination with rifampicin for the treatment of a variety of dermatological disorders such as acne, dermatitis herpetiformis, psoriasis, Toxoplasma gondii infections, leprosy and pneumocystis carinii pneumonia in AIDS patients. However, the clinical use of dapsone is limited because of dose-dependent adverse hematological reactions. The cholestatic injury caused by dapsone and its N- hydroxylated metabolites hinders bile flow and causes oxidative stress and hepatic necrosis, further, leading to hemolysis responsible for hepatitis due to iron overload in the liver. Hence, clinicians' awareness of the hepatotoxic potential of dapsone is highly warranted.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dapsona
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Chem Toxicol
Año:
2021
Tipo del documento:
Article
País de afiliación:
India