AIE-active polysiloxane-based fluorescent probe for identifying cancer cells by locating lipid drops.
Anal Chim Acta
; 1091: 88-94, 2019 Dec 24.
Article
en En
| MEDLINE
| ID: mdl-31679578
ABSTRACT
Comparing with normal cells, Lipid droplets (LDs) of cancer cells show lower polarity and less quantity, which can be utilized as a marker for cancer diagnosis. However, the investigation of LDs in living cancer cells is restricted by the lack of effective molecular tools. Herein, we first reported a novel polysiloxane-based polymer fluorescent polar probe TR-1 with AIE properties, which realized the possibilities for locating LDs. It can aggregate in the LDs of cancer cells and show a stronger fluorescent signal to conduct cancer diagnosis. Moreover, the excellent photostability of TR-1 enable stable fluorescence to exhibit in cancer cells during effective time.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Siloxanos
/
Gotas Lipídicas
/
Colorantes Fluorescentes
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Anal Chim Acta
Año:
2019
Tipo del documento:
Article