Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws.
Cell Rep
; 29(8): 2192-2201.e3, 2019 11 19.
Article
en En
| MEDLINE
| ID: mdl-31747594
ABSTRACT
Mechanosensory neurons across physiological systems sense force using diverse terminal morphologies. Arterial baroreceptors are sensory neurons that monitor blood pressure for real-time stabilization of cardiovascular output. Various aortic sensory terminals have been described, but those that sense blood pressure are unclear because of a lack of selective genetic tools. Here, we find that all baroreceptor neurons are marked in Piezo2-ires-Cre mice and then use genetic approaches to visualize the architecture of mechanosensory endings. Cre-guided ablation of vagal and glossopharyngeal PIEZO2 neurons eliminates the baroreceptor reflex and aortic depressor nerve effects on blood pressure and heart rate. Genetic mapping reveals that PIEZO2 neurons form a distinctive mechanosensory structure macroscopic claws that surround the aortic arch and exude fine end-net endings. Other arterial sensory neurons that form flower-spray terminals are dispensable for baroreception. Together, these findings provide structural insights into how blood pressure is sensed in the aortic vessel wall.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Presorreceptores
/
Sistema Nervioso Autónomo
/
Presión Sanguínea
/
Interocepción
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Ganglio Nudoso
Límite:
Animals
Idioma:
En
Revista:
Cell Rep
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos