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The adaptive response to iron involves changes in energetic strategies in the pathogen Candida albicans.
Duval, Celia; Macabiou, Carole; Garcia, Camille; Lesuisse, Emmanuel; Camadro, Jean-Michel; Auchère, Françoise.
Afiliación
  • Duval C; Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
  • Macabiou C; Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
  • Garcia C; Plateforme Protéomique structurale et fonctionnelle/Spectrométrie de masse, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
  • Lesuisse E; Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
  • Camadro JM; Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
  • Auchère F; Laboratoire Mitochondries, Métaux et Stress Oxydant, Institut Jacques Monod, UMR 7592, Université Paris-Diderot/CNRS (USPC), Paris, France.
Microbiologyopen ; 9(2): e970, 2020 02.
Article en En | MEDLINE | ID: mdl-31788966
ABSTRACT
Candida albicans is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases known as candidiasis. Its ability to grow in different morphological forms, such as yeasts or filamentous hyphae, contributes to its survival in diverse microenvironments. Iron uptake has been associated with virulence, and C. albicans has developed elaborate strategies for acquiring iron from its host. In this work, we analyze the metabolic changes in response to changes in iron content in the growth medium and compare C. albicans adaptation to the presence or absence of iron. Functional and morphological studies, correlated to a quantitative proteomic analysis, were performed to assess the specific pathways underlying the response to iron, both in the yeast and filamentous forms. Overall, the results show that the adaptive response to iron is associated with a metabolic remodeling affecting the energetic pathways of the pathogen. This includes changes in the thiol-dependent redox status, the activity of key mitochondrial enzymes and the respiratory chain. Iron deficiency stimulates bioenergetic pathways, whereas iron-rich condition is associated with greater biosynthetic needs, particularly in filamentous forms. Moreover, we found that C. albicans yeast cells have an extraordinary capability to adapt to changes in environmental conditions.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Adaptación Biológica / Metabolismo Energético / Hierro Idioma: En Revista: Microbiologyopen Año: 2020 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Adaptación Biológica / Metabolismo Energético / Hierro Idioma: En Revista: Microbiologyopen Año: 2020 Tipo del documento: Article País de afiliación: Francia