Peptide-Based Vaccines: Current Progress and Future Challenges.
Chem Rev
; 120(6): 3210-3229, 2020 03 25.
Article
en En
| MEDLINE
| ID: mdl-31804810
ABSTRACT
Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vacunas de Subunidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Rev
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos