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Period 2-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Zhang, Xin-Yu; Wang, Lin; Yan, Wen-Jiang; Lu, Xiao-Ting; Li, Xin-Yun; Sun, Yuan-Yuan.
Afiliación
  • Zhang XY; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong Unive
  • Wang L; Grade 2016, School of Basic Medical Sciences, Clinical Medicine (5 + 3), Shandong University, Jinan, China.
  • Yan WJ; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong Unive
  • Lu XT; Department of Gerontology, The Second Hospital of Shandong University, Jinan, China.
  • Li XY; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong Unive
  • Sun YY; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong Unive
Hum Gene Ther ; 31(1-2): 119-128, 2020 01.
Article en En | MEDLINE | ID: mdl-31822134
Accumulating evidence indicates that the onset of myocardial infarction (MI) shows obvious circadian rhythmicity. Clinical studies have shown that MIs that occur in the early morning have a poor prognosis, but the mechanisms involved are still unknown. In this study, we showed that the expression level of Period 2 (per2) in the heart of mice is lower in the early morning than at noon and that increasing the expression of per2 in H9C2 cells and rat cardiomyocytes increases autophagy levels. Further studies indicated that overexpression of per2 after an MI improved cardiac function by increasing autophagy. In summary, this study has shown that the circadian clock protein, per2, may be a regulator of MI.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Remodelación Ventricular / Proteínas Circadianas Period / Infarto del Miocardio Límite: Animals Idioma: En Revista: Hum Gene Ther Asunto de la revista: GENETICA MEDICA / TERAPEUTICA Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Remodelación Ventricular / Proteínas Circadianas Period / Infarto del Miocardio Límite: Animals Idioma: En Revista: Hum Gene Ther Asunto de la revista: GENETICA MEDICA / TERAPEUTICA Año: 2020 Tipo del documento: Article