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Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.
Fujiwara, Hiroaki; Tateishi, Keisuke; Misumi, Kento; Hayashi, Akimasa; Igarashi, Kaori; Kato, Hiroyuki; Nakatsuka, Takuma; Suzuki, Nobumi; Yamamoto, Keisuke; Kudo, Yotaro; Hayakawa, Yoku; Nakagawa, Hayato; Tanaka, Yasuo; Ijichi, Hideaki; Kogure, Hirofumi; Nakai, Yosuke; Isayama, Hiroyuki; Hasegawa, Kiyoshi; Fukayama, Masashi; Soga, Tomoyoshi; Koike, Kazuhiko.
Afiliación
  • Fujiwara H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Tateishi K; Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Bakurocho, Chuo-ku, Tokyo, 103-0002, Japan.
  • Misumi K; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ktate-tky@umin.ac.jp.
  • Hayashi A; Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Igarashi K; Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kato H; Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.
  • Nakatsuka T; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Suzuki N; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Yamamoto K; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kudo Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Hayakawa Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Nakagawa H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Tanaka Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Ijichi H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Kogure H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Nakai Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Isayama H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Hasegawa K; Department of Gastroenterology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
  • Fukayama M; Hepato-Biliary-Pancreatic Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Soga T; Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
  • Koike K; Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.
Sci Rep ; 9(1): 18859, 2019 12 11.
Article en En | MEDLINE | ID: mdl-31827136
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sistema Biliar / Fosfofructoquinasa-1 / Proteínas Quinasas Activadas por AMP / Isocitrato Deshidrogenasa / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sistema Biliar / Fosfofructoquinasa-1 / Proteínas Quinasas Activadas por AMP / Isocitrato Deshidrogenasa / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Japón