Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine.
Ocul Immunol Inflamm
; 29(2): 278-281, 2021 Feb 17.
Article
en En
| MEDLINE
| ID: mdl-31829774
ABSTRACT
Purpose:
To report a series of cases demonstrating the resolution of Acanthamoeba keratitis (AK) with adjunctive use of oral miltefosine.Methods:
Retrospective case series.Results:
The first case was a 27-year-old female who presented with severe pain and photophobia. The diagnosis of AK was made with confocal microscopy, which revealed a significant burden of stromal cysts. After approximately 2 weeks of adjunctive oral miltefosine therapy, there was a severe inflammatory response within the cornea followed by quick resolution of the AK. The second case was a 31-year-old male in whom the diagnosis of AK was confirmed by culture and polymerase chain reaction. Adjunctive oral miltefosine was started 3 months after presentation, leading to a quick resolution.Conclusions:
Oral miltefosine may have cysticidal properties and should be considered as adjunctive therapy for the treatment of AK, particularly in cases with a significant burden of cysts or in cases recalcitrant to other treatments.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosforilcolina
/
Agudeza Visual
/
Queratitis por Acanthamoeba
/
Infecciones Parasitarias del Ojo
/
Córnea
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ocul Immunol Inflamm
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
OFTALMOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos