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NHC-catalyzed silylative dehydration of primary amides to nitriles at room temperature.
Hota, Pradip Kumar; Maji, Subir; Ahmed, Jasimuddin; Rajendran, N M; Mandal, Swadhin K.
Afiliación
  • Hota PK; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India. swadhin.mandal@iiserkol.ac.in.
  • Maji S; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India. swadhin.mandal@iiserkol.ac.in.
  • Ahmed J; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India. swadhin.mandal@iiserkol.ac.in.
  • Rajendran NM; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India. swadhin.mandal@iiserkol.ac.in.
  • Mandal SK; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India. swadhin.mandal@iiserkol.ac.in.
Chem Commun (Camb) ; 56(4): 575-578, 2020 Jan 14.
Article en En | MEDLINE | ID: mdl-31830152
ABSTRACT
Herein we report an abnormal N-heterocyclic carbene catalyzed dehydration of primary amides in the presence of a silane. This process bypasses the energy demanding 1,2-siloxane elimination step usually required for metal/silane catalyzed reactions. A detailed mechanistic cycle of this process has been proposed based on experimental evidence along with computational study.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: India
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: India