[Prevalence of extended-spectrum beta-lactamases in enterobacteria of neonatal sepsis and associated factors]. / Prevalencia de ß-lactamasas de espectro extendido en enterobacterias causantes de sepsis neonatal y factores asociados.
Rev Chilena Infectol
; 36(4): 433-441, 2019 Aug.
Article
en Es
| MEDLINE
| ID: mdl-31859766
ABSTRACT
BACKGROUND:
Infections caused by extended-spectrum beta-lactamases enterobacteria (ESBL-EP) have implications for neonatal morbidity and mortality.AIM:
To describe the prevalence of ESBL-EP in neonatal sepsis and associated factors.METHODS:
A prospective cohort study was conducted from August 2016 to August 2017; newborn babies (NB) hospitalized in the Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" were included. The ESBL-EP were investigated by double-disk synergy test and its association with clinical and demographic characteristics of the NB.RESULTS:
A total of 1,501 hospitalized NB were studied, with an average gestational age of 36.3 weeks. They were diagnosed 196 neonatal sepsis events, the most frequent etiologies were enterobacteria (45.5%). Resistance to ampicilin was found in 88.8% and to broad spectrum cephalosporins in more than 42% of the strains; 22.9% of them were ESBL phenotype. Apgar ≤ 7 at five minutes of life (OR 4.6; 95% CI 1.47-14.6) and gestational age < 37 weeks (OR 5.4; 95% CI 1.04-27.) increase the risk.CONCLUSION:
In enterobacteria that cause neonatal sepsis, 22.9% were EP-ESBL; infection was more likely in patients with Apgar ≤ 7 at five minutes of age and in preterm infants.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Beta-Lactamasas
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Infección Hospitalaria
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Enterobacteriaceae
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Infecciones por Enterobacteriaceae
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Sepsis Neonatal
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Antibacterianos
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
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Newborn
Idioma:
Es
Revista:
Rev Chilena Infectol
Año:
2019
Tipo del documento:
Article