The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.

Qin, Zhihua; Bonifati, Serena; St Gelais, Corine; Li, Tai-Wei; Kim, Sun-Hee; Antonucci, Jenna M; Mahboubi, Bijan; Yount, Jacob S; Xiong, Yong; Kim, Baek; Wu, Li

Qin, Zhihua; Bonifati, Serena; St Gelais, Corine; Li, Tai-Wei; Kim, Sun-Hee; Antonucci, Jenna M; Mahboubi, Bijan; Yount, Jacob S; Xiong, Yong; Kim, Baek; Wu, Li.

Afiliación

Qin Z; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Bonifati S; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
St Gelais C; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Li TW; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Kim SH; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Antonucci JM; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Mahboubi B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Yount JS; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210.
Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520.
Kim B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Wu L; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242; Department of Microbial Infection and Immunity, Infectious Diseases

J Biol Chem ; 295(6): 1575-1586, 2020 02 07.

Article en En | MEDLINE | ID: mdl-31914403

Asunto(s)

Inmunidad Innata; Monocitos/inmunología; Proteína 1 que Contiene Dominios SAM y HD/inmunología; Núcleo Celular/inmunología; Humanos; Infecciones por Respirovirus/inmunología; Proteína 1 que Contiene Dominios SAM y HD/análisis; Virus Sendai/inmunología; Células THP-1; Células U937

Palabras clave

NF-kB transcription factor; NF-kappa B (NF-KB); NF-κB activation; SAM domain and HD domain-containing protein 1 (SAMHD1); SAMHD1; cell differentiation; dNTPase activity; inflammation; innate immune responses; innate immunity; interferon; monocyte; monocytic cells; nuclear localization; type I interferon (IFN-I); viral restriction factor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Monocitos / Proteína 1 que Contiene Dominios SAM y HD / Inmunidad Innata Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article

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