Clozapine toxicity: a cautionary palliative care tale.
BMJ Support Palliat Care
; 10(3): 312-313, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31932474
ABSTRACT
OBJECTIVE:
This case report presents an unusual case of clozapine toxicity secondary to reduced smoking habit mimicking a patient approaching end of life.METHODS:
It is a cautionary tale for palliative care specialists, perhaps unaware of the effect of cigarette smoke on metabolism of this antipsychotic, to be aware of.RESULTS:
Following specialist advice and change of antipsychotic medication, this patient's condition improved to the point that he was discharged from the hospice.CONCLUSION:
Palliative care specialists should be aware that reducing cigarette consumption can alter metabolism of clozapine, potentially causing drug accumulation and toxicity with features which mimic deterioration towards end of life. Specialist advice should be sought in such a situation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Fumar
/
Cese del Hábito de Fumar
/
Clozapina
/
Letargia
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
BMJ Support Palliat Care
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido