Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication.

Kupke, Sascha Young; Ly, Lam-Ha; Börno, Stefan Thomas; Ruff, Alexander; Timmermann, Bernd; Vingron, Martin; Haas, Stefan; Reichl, Udo

Kupke, Sascha Young; Ly, Lam-Ha; Börno, Stefan Thomas; Ruff, Alexander; Timmermann, Bernd; Vingron, Martin; Haas, Stefan; Reichl, Udo.

Afiliación

Kupke SY; Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany.
Ly LH; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Börno ST; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Ruff A; Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany.
Timmermann B; Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Vingron M; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Haas S; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Reichl U; Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany.

Viruses ; 12(1)2020 01 07.

Article en En | MEDLINE | ID: mdl-31936115

Asunto(s)

Virus Defectuosos/genética; Variación Genética; Virus de la Influenza A/genética; ARN Viral/genética; Análisis de la Célula Individual; Replicación Viral; Animales; Perros; Secuenciación de Nucleótidos de Alto Rendimiento; Virus de la Influenza A/fisiología; Células de Riñón Canino Madin Darby

Palabras clave

cell-to-cell heterogeneity; defective interfering particles; influenza A virus; next-generation sequencing; single-cell RNA sequencing; single-cell analysis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Variación Genética / Replicación Viral / ARN Viral / Virus Defectuosos / Análisis de la Célula Individual Límite: Animals Idioma: En Revista: Viruses Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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