A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.

Li, Zhongchi; Xu, Kang; Guo, Yannan; Ping, Lu; Gao, Yuqi; Qiu, Ying; Ni, Jianquan; Liu, Qingfei; Wang, Zhao

Li, Zhongchi; Xu, Kang; Guo, Yannan; Ping, Lu; Gao, Yuqi; Qiu, Ying; Ni, Jianquan; Liu, Qingfei; Wang, Zhao.

Afiliación

Li Z; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xu K; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Guo Y; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Ping L; 8-year MD Program, Peking Union Medical College, Beijing, China.
Gao Y; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Qiu Y; School of Medicine, Tsinghua University, Beijing, China.
Ni J; School of Medicine, Tsinghua University, Beijing, China.
Liu Q; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Wang Z; Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.

Aging Cell ; 19(3): e13104, 2020 03.

Article en En | MEDLINE | ID: mdl-31967391

Asunto(s)

Envejecimiento Prematuro/metabolismo; Dieta Alta en Grasa; Factor I del Crecimiento Similar a la Insulina/metabolismo; Insulina/metabolismo; Enfermedades Metabólicas/metabolismo; Transducción de Señal/genética; Sirtuinas/deficiencia; Envejecimiento Prematuro/genética; Animales; Peso Corporal; Ácidos Grasos/metabolismo; Femenino; Glucosa/metabolismo; Glucólisis; Longevidad; Masculino; Enfermedades Metabólicas/genética; Ratones; Ratones Noqueados; Sirtuinas/genética

Palabras clave

SIRT6; fatty acid; glycolysis; high-fat diet; insulin/IGF1 signaling; organ atrophy

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Transducción de Señal / Envejecimiento Prematuro / Sirtuinas / Dieta Alta en Grasa / Insulina / Enfermedades Metabólicas Límite: Animals Idioma: En Revista: Aging Cell Año: 2020 Tipo del documento: Article País de afiliación: China

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