HISTOLOGIC FINDINGS IN VITREORETINAL LYMPHOMA: Learning From Enucleation Specimens.
Retina
; 40(2): 391-398, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31972811
ABSTRACT
PURPOSE:
We aimed to describe the clinical and histologic findings in a few enucleation cases with intraocular lymphoma.METHODS:
Retrospective review of pathology files from a 22-year period identified cases with intraocular lymphoma among all enucleation specimens. Patient demographics, clinical findings, laboratory results, radiographic studies, and indication for enucleation were abstracted from electronic health records; slides were reviewed.RESULTS:
Four patients (three women and one man; age range, sixth through eighth decades of life) underwent enucleation with a final diagnosis of intraocular lymphoma. Two patients with primary vitreoretinal large B-cell lymphomas had been treated for refractory uveitis. Specimens showed retinal and subretinal infiltrates by atypical large B-lymphocytes and rare neoplastic cells in the vitreous. The remaining two patients had systemic lymphoproliferative disorders. One patient had chronic lymphocytic leukemia and floaters in his eye; vitreoretinal lymphoma developed, consistent with intraocular Richter transformation. The other had diffuse large B-cell lymphoma in remission; however, blurred vision developed, she was treated for panuveitis without improvement, and was later found to have ocular involvement by diffuse large B-cell lymphoma.CONCLUSION:
Our series details the unusual circumstances when an eye is removed for intraocular lymphoma. Different patterns of ocular tissue involvement were observed when we compared primary and secondary lymphomas.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retina
/
Cuerpo Vítreo
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Enucleación del Ojo
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Linfoma de Células B Grandes Difuso
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Neoplasias de la Retina
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Tomografía de Coherencia Óptica
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Linfoma Intraocular
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Retina
Año:
2020
Tipo del documento:
Article