Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition.
Curr Diabetes Rev
; 16(8): 797-806, 2020.
Article
en En
| MEDLINE
| ID: mdl-32000646
ABSTRACT
Diabetes mellitus is associated with an increased risk of micro and macrovascular complications. During hyperglycemic conditions, endothelial cells and vascular smooth muscle cells are exquisitely sensitive to high glucose. This high glucose-induced sustained reactive oxygen species production leads to redox imbalance, which is associated with endothelial dysfunction and vascular wall remodeling. Nrf2, a redox-regulated transcription factor plays a key role in the antioxidant response element (ARE)-mediated expression of antioxidant genes. Although accumulating data indicate the molecular mechanisms underpinning the Nrf2 regulated redox balance, understanding the influence of the Nrf2/ARE axis during hyperglycemic condition on vascular cells is paramount. This review focuses on the context-dependent role of Nrf2/ARE signaling on vascular endothelial and smooth muscle cell function during hyperglycemic conditions. This review also highlights improving the Nrf2 system in vascular tissues, which could be a potential therapeutic strategy for vascular dysfunction.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Miocitos del Músculo Liso
/
Células Endoteliales
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Diabetes Mellitus Tipo 2
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Factor 2 Relacionado con NF-E2
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Elementos de Respuesta Antioxidante
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Hiperglucemia
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Diabetes Rev
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
India