Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy.
Methods Mol Biol
; 2115: 79-90, 2020.
Article
en En
| MEDLINE
| ID: mdl-32006395
ABSTRACT
The silencing of an oncogene with a small interfering RNA (siRNA) is a promising way for cancer therapy. Its efficacy can be further enhanced by integrating with other therapeutics; however, transporting siRNA and other active ingredients to the same location at the same time is challenging. Here, we report a novel multifunctional nanodelivery platform by sequentially layering several functional ingredients, such as siRNAs, microRNAs, peptides, and targeting ligands, onto a core through charge-charge interaction. The prepared nanovectors effectively and programmably delivered multiple active components to maximize therapeutic combination with minimal off-targeting effects.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Portadores de Fármacos
/
ARN Interferente Pequeño
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Nanopartículas
/
Neoplasias
Límite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos