Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells.

Sudowe, Stephan; Höhn, Yvonne; Renzing, Andrea; Maxeiner, Joachim; Montermann, Evelyn; Habermeier, Alice; Closs, Ellen; Bros, Matthias; Reske-Kunz, Angelika B

Sudowe, Stephan; Höhn, Yvonne; Renzing, Andrea; Maxeiner, Joachim; Montermann, Evelyn; Habermeier, Alice; Closs, Ellen; Bros, Matthias; Reske-Kunz, Angelika B.

Afiliación

Sudowe S; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Höhn Y; Ganzimmun Diagnostics AG, Mainz, Germany.
Renzing A; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Maxeiner J; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Montermann E; III. Medical Department, Asthma Core Facility, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Habermeier A; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Closs E; Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Bros M; Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Reske-Kunz AB; Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. mbros@uni-mainz.de.

Amino Acids ; 52(3): 411-424, 2020 Mar.

Article en En | MEDLINE | ID: mdl-32008091

Asunto(s)

Asma/terapia; Biolística/métodos; Hiperreactividad Bronquial/terapia; Células Dendríticas/inmunología; Indolamina-Pirrol 2,3,-Dioxigenasa/genética; Vacunación/métodos; Animales; Antígenos/genética; Antígenos/inmunología; Asma/inmunología; Hiperreactividad Bronquial/inmunología; Proteínas Portadoras/genética; Vectores Genéticos; Ratones; Ratones Endogámicos BALB C; Proteínas de Microfilamentos/genética; Células 3T3 NIH; Infiltración Neutrófila; Linfocitos T Citotóxicos/inmunología; Células TH1/inmunología; Transgenes; beta-Galactosidasa/genética; beta-Galactosidasa/inmunología

Palabras clave

Allergic airway inflammation; DNA vaccination; Dendritic cells; Fascin promoter; Indoleamine 2,3-dioxygenase (IDO); Particle-mediated epidermal delivery (PMED)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Células Dendríticas / Vacunación / Hiperreactividad Bronquial / Biolística / Indolamina-Pirrol 2,3,-Dioxigenasa Límite: Animals Idioma: En Revista: Amino Acids Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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