Reaction of carbon monoxide with cystathionine ß-synthase: implications on drug efficacies in cancer chemotherapy.
Future Med Chem
; 12(4): 325-337, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-32031001
ABSTRACT
Photo-activatable carbon monoxide (CO)-releasing molecules (photoCORMs), have recently provided help to identify the salutary effects of CO in human pathophysiology. Among them notable is the ability of CO to sensitize chemotherapeutic-resistant cancer cells. Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine ß-synthase (CBS), a key regulator of redox homeostasis in the cell. Diminution of the antioxidant capacity of cancer cells leads to sensitization to reactive oxygen species-producing drugs like doxorubicin and paclitaxel upon cotreatment with CO as well as in mitigating the drug effects of cisplatin. We hypothesize that the development of CO delivery techniques for coadministration with existing cancer treatment regimens may ultimately improve clinical outcomes in cancer therapy.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Monóxido de Carbono
/
Doxorrubicina
/
Paclitaxel
/
Cistationina betasintasa
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Neoplasias
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Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos