New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection.

Andersson, Jourdan A; Peniche, Alex G; Galindo, Cristi L; Boonma, Prapaporn; Sha, Jian; Luna, Ruth Ann; Savidge, Tor C; Chopra, Ashok K; Dann, Sara M

Andersson, Jourdan A; Peniche, Alex G; Galindo, Cristi L; Boonma, Prapaporn; Sha, Jian; Luna, Ruth Ann; Savidge, Tor C; Chopra, Ashok K; Dann, Sara M.

Afiliación

Andersson JA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Peniche AG; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Galindo CL; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA.
Boonma P; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Sha J; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Luna RA; Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Savidge TC; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Chopra AK; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
Dann SM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.

mBio ; 11(2)2020 03 10.

Article en En | MEDLINE | ID: mdl-32156806

Asunto(s)

Amoxapina/uso terapéutico; Infecciones por Clostridium/tratamiento farmacológico; Doxapram/uso terapéutico; Inmunidad Innata; Microbiota/efectos de los fármacos; Trifluoperazina/uso terapéutico; Animales; Clostridioides difficile/efectos de los fármacos; Reposicionamiento de Medicamentos; Femenino; Inmunomodulación; Masculino; Ratones; Ratones Endogámicos C57BL; Microbiota/inmunología; RNA-Seq; Organismos Libres de Patógenos Específicos

Palabras clave

Clostridioides difficile; germfree mice; host-directed therapeutics; mechanism of action; microbiota; mouse model of infection

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trifluoperazina / Infecciones por Clostridium / Doxapram / Microbiota / Amoxapina / Inmunidad Innata Límite: Animals Idioma: En Revista: MBio Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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