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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
Kumar, Pawan; Degaonkar, Rohan; Guenther, Dale C; Abramov, Mikhail; Schepers, Guy; Capobianco, Marie; Jiang, Yongfeng; Harp, Joel; Kaittanis, Charalambos; Janas, Maja M; Castoreno, Adam; Zlatev, Ivan; Schlegel, Mark K; Herdewijn, Piet; Egli, Martin; Manoharan, Muthiah.
Afiliación
  • Kumar P; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Degaonkar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Guenther DC; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Abramov M; Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Schepers G; Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Capobianco M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Jiang Y; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Harp J; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
  • Kaittanis C; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Janas MM; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Castoreno A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Zlatev I; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Schlegel MK; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
  • Herdewijn P; Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
  • Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
  • Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
Nucleic Acids Res ; 48(8): 4028-4040, 2020 05 07.
Article en En | MEDLINE | ID: mdl-32170309
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetilgalactosamina / Alcoholes del Azúcar / Carbohidratos / ARN Interferente Pequeño / Interferencia de ARN Límite: Animals Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetilgalactosamina / Alcoholes del Azúcar / Carbohidratos / ARN Interferente Pequeño / Interferencia de ARN Límite: Animals Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos