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Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [11C]CO2 fixation method.
Chen, Zhen; Chen, Jiahui; Mast, Natalia; Rong, Jian; Deng, Xiaoyun; Shao, Tuo; Fu, Hualong; Yu, Qingzhen; Sun, Jiyun; Shao, Yihan; Josephson, Lee; Collier, Thomas Lee; Pikuleva, Irina; Liang, Steven H.
Afiliación
  • Chen Z; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Chen J; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Mast N; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Rong J; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Deng X; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Shao T; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Fu H; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Yu Q; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Sun J; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Shao Y; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
  • Josephson L; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Collier TL; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.
  • Pikuleva I; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Liang SH; Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA 02114, USA. Electronic address: Liang.Steven@mgh.harvard.edu.
Bioorg Med Chem Lett ; 30(9): 127068, 2020 05 01.
Article en En | MEDLINE | ID: mdl-32178974
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dióxido de Carbono / Isótopos de Carbono / Radiofármacos / Inhibidores Enzimáticos / Colesterol 24-Hidroxilasa Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dióxido de Carbono / Isótopos de Carbono / Radiofármacos / Inhibidores Enzimáticos / Colesterol 24-Hidroxilasa Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos