The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.

Cannata, Attilio; De Luca, Chiara; Korkina, Liudmila G; Ferlazzo, Nadia; Ientile, Riccardo; Currò, Monica; Andolina, Giulia; Caccamo, Daniela

Cannata, Attilio; De Luca, Chiara; Korkina, Liudmila G; Ferlazzo, Nadia; Ientile, Riccardo; Currò, Monica; Andolina, Giulia; Caccamo, Daniela.

Afiliación

Cannata A; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
De Luca C; R & D Regulatory Affairs Department, Medena AG, Affoltern-am-Albis (ZH) CH-8910, Switzerland.
Korkina LG; Centre of Innovative Biotechnological Investigations Nanolab (CIBI-NANOLAB), Moscow 119571, Russia.
Ferlazzo N; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Ientile R; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Currò M; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Andolina G; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.
Caccamo D; Department of Biomedical Sciences, Dental Sciences and Morpho-functional Imaging, Polyclinic Hospital University, Messina 989125, Italy.

Int J Mol Sci ; 21(5)2020 Mar 09.

Article en En | MEDLINE | ID: mdl-32182774

Asunto(s)

Citocinas/genética; Leucocitos Mononucleares/fisiología; Sensibilidad Química Múltiple/genética; Polimorfismo de Nucleótido Simple/genética; Receptor de Adenosina A2A/genética; Transcripción Genética/genética; Adulto; Estudios de Casos y Controles; Femenino; Predisposición Genética a la Enfermedad/genética; Genotipo; Humanos; Interferón gamma/genética; Interleucina-4/genética; Masculino; Persona de Mediana Edad; ARN Mensajero/genética

Palabras clave

ADORA2A SNP; ADORA2A gene expression; PBMC; genetic background role; inflammatory cytokines; multiple chemical sensitivity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Leucocitos Mononucleares / Citocinas / Sensibilidad Química Múltiple / Polimorfismo de Nucleótido Simple / Receptor de Adenosina A2A Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia

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