Cytosolic mtDNA released from pneumolysin-damaged mitochondria triggers IFN-ß production in epithelial cells.

Fang, Yuting; Zhang, Xuemei; Lu, Chang; Yin, Yibing; Hu, Xuexue; Xu, Wenchun; Liu, Yusi; Wang, Hong

Fang, Yuting; Zhang, Xuemei; Lu, Chang; Yin, Yibing; Hu, Xuexue; Xu, Wenchun; Liu, Yusi; Wang, Hong.

Afiliación

Fang Y; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Zhang X; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Lu C; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Yin Y; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Hu X; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Xu W; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.
Liu Y; Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China.
Wang H; School of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing 400016, People's Republic of China.

Can J Microbiol ; 66(7): 435-445, 2020 Jul.

Article en En | MEDLINE | ID: mdl-32191844

Asunto(s)

Citosol/metabolismo; ADN Mitocondrial/metabolismo; Interferón beta/metabolismo; Mitocondrias/efectos de los fármacos; Estreptolisinas/toxicidad; Animales; Proteínas Bacterianas/toxicidad; Líquido del Lavado Bronquioalveolar/química; Líquido del Lavado Bronquioalveolar/microbiología; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Humanos; Ratones; Mitocondrias/metabolismo; Mitocondrias/patología; Streptococcus pneumoniae/patogenicidad

Palabras clave

ADNmt; IFN-ß; cellules épithéliales; dommage mitochondrial; epithelial cells; mitochondrial damage; mtDNA; pneumolysin (Ply); pneumolysine (Ply)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estreptolisinas / ADN Mitocondrial / Interferón beta / Citosol / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Can J Microbiol Año: 2020 Tipo del documento: Article

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