Design, Synthesis, Biological Evaluation and Inhibition Mechanism of 3-/4-Alkoxy Phenylethylidenethiosemicarbazides as New, Potent and Safe Tyrosinase Inhibitors.

Song, Senchuan; Mai, Yuliang; Shi, Huahong; Liao, Bing; Wang, Fei

Song, Senchuan; Mai, Yuliang; Shi, Huahong; Liao, Bing; Wang, Fei.

Afiliación

Song S; Guangdong Research Institute of Petrochemical and Fine Chemical Engineering, Guangdong Academy of Sciences.
Mai Y; Guangdong Research Institute of Petrochemical and Fine Chemical Engineering, Guangdong Academy of Sciences.
Shi H; Guangdong Research Institute of Petrochemical and Fine Chemical Engineering, Guangdong Academy of Sciences.
Liao B; Guangdong Research Institute of Petrochemical and Fine Chemical Engineering, Guangdong Academy of Sciences.
Wang F; Guangdong Research Institute of Petrochemical and Fine Chemical Engineering, Guangdong Academy of Sciences.

Chem Pharm Bull (Tokyo) ; 68(4): 369-379, 2020.

Article en En | MEDLINE | ID: mdl-32238654

Asunto(s)

Diseño de Fármacos; Inhibidores Enzimáticos/farmacología; Monofenol Monooxigenasa/antagonistas & inhibidores; Semicarbacidas/farmacología; Agaricales/enzimología; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Células HEK293; Humanos; Cinética; Estructura Molecular; Monofenol Monooxigenasa/metabolismo; Semicarbacidas/síntesis química; Semicarbacidas/química; Relación Estructura-Actividad

Palabras clave

cytotoxicity; inhibition mechanism; inhibitory kinetics; structureactivity relationship; thiosemicarbazone; tyrosinase inhibitor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Semicarbacidas / Diseño de Fármacos / Monofenol Monooxigenasa / Inhibidores Enzimáticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Chem Pharm Bull (Tokyo) Año: 2020 Tipo del documento: Article

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