Efficacy of Bedaquiline, Alone or in Combination with Imipenem, against Mycobacterium abscessus in C3HeB/FeJ Mice.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Article
en En
| MEDLINE
| ID: mdl-32253217
ABSTRACT
Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics, such as bedaquiline and imipenem, although in vitro data have questioned this combination. We report that the efficacy of bedaquiline-imipenem combination treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus The addition of imipenem contributed to clearing the infection in the spleen.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Mycobacterium abscessus
/
Infecciones por Mycobacterium no Tuberculosas
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia