Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.

Jain, Isha H; Calvo, Sarah E; Markhard, Andrew L; Skinner, Owen S; To, Tsz-Leung; Ast, Tslil; Mootha, Vamsi K

Jain, Isha H; Calvo, Sarah E; Markhard, Andrew L; Skinner, Owen S; To, Tsz-Leung; Ast, Tslil; Mootha, Vamsi K.

Afiliación

Jain IH; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
Calvo SE; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
Markhard AL; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
Skinner OS; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
To TL; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
Ast T; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA.
Mootha VK; Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address: vamsi@hms.harvard.edu.

Cell ; 181(3): 716-727.e11, 2020 04 30.

Article en En | MEDLINE | ID: mdl-32259488

Asunto(s)

Metabolismo de los Lípidos/genética; Mitocondrias/genética; Oxígeno/metabolismo; Transcriptoma/genética; Hipoxia de la Célula; Pruebas Genéticas/métodos; Estudio de Asociación del Genoma Completo/métodos; Células HEK293; Humanos; Hipoxia/metabolismo; Células K562; Metabolismo de los Lípidos/fisiología; Lípidos/genética; Lípidos/fisiología; Mitocondrias/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/fisiología

Palabras clave

CoQ biosynthesis; FASII; MPC; TMEM189; hypoxia; iron-sulfur clusters; membrane fluidity; plasmalogens; pyruvate dehydrogenase; type II fatty acid synthesis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxígeno / Metabolismo de los Lípidos / Transcriptoma / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google