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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic, Angela; Brand, Theresa; Schanbacher, Constanze; Kramer, Sofia; Hümmert, Martin W; Godoy, Patricio; Schmidt-Heck, Wolfgang; Nordbeck, Peter; Ludwig, Jonas; Homann, Susanne; Wiegering, Armin; Shaykhutdinov, Timur; Kratz, Christoph; Knüchel, Ruth; Müller-Hermelink, Hans-Konrad; Rosenwald, Andreas; Frey, Norbert; Eichler, Jutta; Dobrev, Dobromir; El-Armouche, Ali; Hengstler, Jan G; Müller, Oliver J; Hinrichs, Karsten; Cuello, Friederike; Zernecke, Alma; Lorenz, Kristina.
Afiliación
  • Tomasovic A; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Brand T; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
  • Schanbacher C; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Kramer S; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
  • Hümmert MW; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Godoy P; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 44139, Dortmund, Germany.
  • Schmidt-Heck W; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Nordbeck P; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Ludwig J; Department of Neurology, Hannover Medical School, 30625, Hannover, Germany.
  • Homann S; IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, 44139, Dortmund, Germany.
  • Wiegering A; Leibniz Institute for Natural Product Research and Infection Biology -Hans Knoell Institute-, 07745, Jena, Germany.
  • Shaykhutdinov T; Comprehensive Heart Failure Center, 97078, Würzburg, Germany.
  • Kratz C; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.
  • Knüchel R; Institute of Pharmacology and Toxicology, University of Würzburg, 97078, Würzburg, Germany.
  • Müller-Hermelink HK; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, 97080, Würzburg, Germany.
  • Rosenwald A; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 12489, Berlin, Germany.
  • Frey N; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., 12489, Berlin, Germany.
  • Eichler J; Institute of Pathology, University Hospital Aachen, RWTH Aachen, 52074, Aachen, Germany.
  • Dobrev D; Institute of Pathology, University of Würzburg, 97080, Würzburg, Germany.
  • El-Armouche A; Institute of Pathology, University of Würzburg, 97080, Würzburg, Germany.
  • Hengstler JG; Department of Internal Medicine III, University of Kiel, 24105, Kiel, Germany.
  • Müller OJ; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Kiel, Germany.
  • Hinrichs K; Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.
  • Cuello F; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, 45147, Essen, Germany.
  • Zernecke A; Department of Pharmacology and Toxicology, TU Dresden, 01307, Dresden, Germany.
  • Lorenz K; IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, 44139, Dortmund, Germany.
Nat Commun ; 11(1): 1733, 2020 04 07.
Article en En | MEDLINE | ID: mdl-32265441
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dimerización / Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular / Péptidos de Penetración Celular / Cardiotoxicidad Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dimerización / Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular / Péptidos de Penetración Celular / Cardiotoxicidad Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania