Early pregnancy prediction of gestational diabetes mellitus risk using prenatal screening biomarkers in nulliparous women.
Diabetes Res Clin Pract
; 163: 108139, 2020 May.
Article
en En
| MEDLINE
| ID: mdl-32272192
ABSTRACT
AIMS:
To evaluate the clinical utility of first and second trimester prenatal screening biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM) risk in nulliparous women.METHODS:
We conducted a population-based cohort study of nulliparous women participating in the California Prenatal Screening Program from 2009 to 2011 (n = 105,379). GDM was ascertained from hospital discharge records or birth certificates. Models including maternal characteristics and prenatal screening biomarkers were developed and validated. Risk stratification and reclassification were performed to assess clinical utility of the biomarkers.RESULTS:
Decreased levels of first trimester pregnancy-associated plasma protein A (PAPP-A) and increased levels of second trimester unconjugated estriol (uE3) and dimeric inhibin A (INH) were associated with GDM. The addition of PAPP-A only and PAPP-A, uE3, and INH to maternal characteristics resulted in small, yet significant, increases in area under the receiver operating characteristic curve (AUC) (maternal characteristics only AUC 0.714 (95% CI 0.703-0.724), maternal characteristics + PAPP-A AUC 0.718 (95% CI 0.707-0.728), maternal characteristics + PAPP-A, uE3, and INH AUC 0.722 (0.712-0.733)); however, no net improvement in classification was observed.CONCLUSIONS:
PAPP-A, uE3, and INH have limited clinical utility for prediction of GDM risk in nulliparous women. Utility of other readily accessible clinical biomarkers in predicting GDM risk warrants further investigation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Prenatal
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Biomarcadores
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Diabetes Gestacional
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Diabetes Res Clin Pract
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos