Prognostic Significance of Lymph Node Status in p16+ Oropharyngeal Cancer After Surgical Treatment.
Laryngoscope
; 130(8): 1973-1979, 2020 08.
Article
en En
| MEDLINE
| ID: mdl-32282081
ABSTRACT
OBJECTIVES/HYPOTHESIS:
In this study, we retrospectively reviewed medical records of patients who underwent surgery for p16+ oropharyngeal cancer and analyzed the prognostic implications of pathologic lymph node (LN) status, including number of metastatic LNs, LN ratio, and location of metastatic LNs. STUDYDESIGN:
Retrospective case series.METHODS:
We retrospectively reviewed data on patients diagnosed with p16+ oropharyngeal cancer.RESULTS:
The study population consisted of 159 males and 29 females with a mean age of 57.2 years. The primary tumor sites were tonsils (n = 160), base of the tongue (n = 24), and soft palate (n = 4). Only recurrence-free survival (RFS) showed a significant correlation with contralateral LN metastasis on multivariate analysis. On Kaplan-Meier analysis, 5-year RFS was 92.4% in patients without contralateral LN metastasis and 68.8% in patients with contralateral LN metastasis.CONCLUSIONS:
Among pathologic LN status in p16+ oropharyngeal cancer, only contralateral LN metastasis showed prognostic significance in disease recurrence of p16+ oropharyngeal squamous cell carcinoma patients. LEVEL OF EVIDENCE 4 Laryngoscope, 130 1973-1979, 2020.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Orofaríngeas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Laryngoscope
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Corea del Sur