Your browser doesn't support javascript.
loading
ANTIGENIC STIMULATION DURING PREGNANCY MODIFIES SPECIFIC IGA1 AND IGA2 SUBCLASSES IN HUMAN COLOSTRUM ACCORDING TO THE CHEMICAL COMPOSITION OF THE ANTIGEN.
Sánchez-Salguero, Erick S; Rodríguez-Chacón, Brenda C; Leyva-Daniel, Jorge; Zambrano-Carrasco, Josué; Miguel-Rodríguez, Carlos E; Santos-Argumedo, Leopoldo.
Afiliación
  • Sánchez-Salguero ES; Department of Molecular Biomedicine, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico.
  • Rodríguez-Chacón BC; Department of Molecular Biomedicine, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico.
  • Leyva-Daniel J; Laboratory of Molecular Microbiology and Environmental Biotechnology, Autonomous University of Guerrero (UAGRO), Chilpancingo, Gro., Mexico.
  • Zambrano-Carrasco J; Department of Molecular Biomedicine, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico.
  • Miguel-Rodríguez CE; Department of Biological Chemistry Sciences, University of Sonora (UNISON), Hermosillo, Son., Mexico.
  • Santos-Argumedo L; Department of Molecular Biomedicine, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico.
Rev Invest Clin ; 72(2): 80-87, 2020.
Article en En | MEDLINE | ID: mdl-32284627
BACKGROUND: Several studies have evaluated the effect of infectious diseases and vaccine protocols during pregnancy on maternal milk immunoglobulin (Ig) levels, to understand the protection conferred by lactation on newborns. Colostrum is the primary source of maternal IgA for the newborn. IgA participates in protection mechanisms in the neonate's mucosa. In humans, IgA has two subclasses with differential anatomical distribution among mucosal compartments. Total IgA levels in maternal milk vary after antigen stimulation and have differential affinities in function of the chemical composition of the antigens. We studied the effect of antigenic stimulation during pregnancy on the concentrations of specific IgA1 and IgA2 subclasses in human colostrum. METHODS: We analyzed data from 113 women in Mexico City and compared the amount of IgA subclasses in colostrum against three antigens: two from vaccine protocols (tetanus toxoid and pneumococcal polysaccharides) and lipopolysaccharide, a ubiquitous antigen in the gastrointestinal tract. RESULTS: In agreement with the previous reports, we showed that IgA1 from colostrum mainly recognized protein antigens; in sharp contrast, IgA2 was mostly directed against polysaccharide antigens. These levels increased in women who had previous contacts through vaccination or infections during pregnancy. CONCLUSIONS: Antigen interaction during pregnancy increased the amount of specific IgA subclasses, depending on the chemical composition of the antigen.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoglobulina A / Calostro / Antígenos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Rev Invest Clin Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: México

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoglobulina A / Calostro / Antígenos Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Rev Invest Clin Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: México