Fundamental control of grade-specific colorectal cancer morphology by Src regulation of ezrin-centrosome engagement.

Rainey, Lisa; Deevi, Ravi K; McClements, Jane; Khawaja, Hajrah; Watson, Chris J; Roudier, Martine; Van Schaeybroeck, Sandra; Campbell, Frederick C

Rainey, Lisa; Deevi, Ravi K; McClements, Jane; Khawaja, Hajrah; Watson, Chris J; Roudier, Martine; Van Schaeybroeck, Sandra; Campbell, Frederick C.

Afiliación

Rainey L; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.
Deevi RK; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.
McClements J; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.
Khawaja H; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.
Watson CJ; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Roudier M; Molecular Pathology Laboratory, AstraZeneca Oncology Translational Science, Cambridge, UK.
Van Schaeybroeck S; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.
Campbell FC; Centre for Cancer Research and Cell Biology, Queen's University Belfast and Belfast Health and Social Care Trust, Belfast, UK.

J Pathol ; 251(3): 310-322, 2020 07.

Article en En | MEDLINE | ID: mdl-32315081

Asunto(s)

Centrosoma/enzimología; Neoplasias Colorrectales/enzimología; Proteínas del Citoesqueleto/metabolismo; Mitosis; Familia-src Quinasas/metabolismo; Células CACO-2; Centrosoma/patología; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/patología; Proteínas del Citoesqueleto/genética; Quinasa 1 de Adhesión Focal/genética; Quinasa 1 de Adhesión Focal/metabolismo; Células HCT116; Humanos; Clasificación del Tumor; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Transducción de Señal; Familia-src Quinasas/genética

Palabras clave

Src; cell division; centrosome; colorectal cancer; ezrin; human; mitotic spindle; phenotype; polo-like kinase; prognosis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Centrosoma / Familia-src Quinasas / Proteínas del Citoesqueleto / Mitosis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Pathol Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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