Antimicrobial evaluation of thiadiazino and thiazolo quinoxaline hybrids as potential DNA gyrase inhibitors; design, synthesis, characterization and morphological studies.

Ammar, Yousry A; Farag, Awatef A; Ali, Abeer M; Hessein, Sadia A; Askar, Ahmed A; Fayed, Eman A; Elsisi, Doaa M; Ragab, Ahmed

Ammar, Yousry A; Farag, Awatef A; Ali, Abeer M; Hessein, Sadia A; Askar, Ahmed A; Fayed, Eman A; Elsisi, Doaa M; Ragab, Ahmed.

Afiliación

Ammar YA; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Farag AA; Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Ali AM; Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Hessein SA; Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Askar AA; Department of Botany and Microbiology, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
Fayed EA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Elsisi DM; Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt. Electronic address: doaa_elsisi@azhar.edu.eg.
Ragab A; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, Egypt. Electronic address: ahmed_ragab@azhar.edu.eg.

Bioorg Chem ; 99: 103841, 2020 06.

Article en En | MEDLINE | ID: mdl-32325335

Asunto(s)

Antibacterianos/farmacología; Antifúngicos/farmacología; Girasa de ADN/metabolismo; Quinoxalinas/farmacología; Tiadiazinas/farmacología; Inhibidores de Topoisomerasa II/farmacología; Animales; Antibacterianos/síntesis química; Antibacterianos/química; Antifúngicos/síntesis química; Antifúngicos/química; Candida albicans/efectos de los fármacos; Chlorocebus aethiops; Relación Dosis-Respuesta a Droga; Diseño de Fármacos; Fusarium/efectos de los fármacos; Bacterias Gramnegativas/efectos de los fármacos; Bacterias Grampositivas/efectos de los fármacos; Bacterias Grampositivas/enzimología; Humanos; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Quinoxalinas/química; Relación Estructura-Actividad; Tiadiazinas/química; Inhibidores de Topoisomerasa II/síntesis química; Inhibidores de Topoisomerasa II/química; Células Vero

Palabras clave

Antimicrobial agents; Bactericidal; Fungistatic; Immunomodulatory; MDRB; Molecular docking; Quinoxaline-6-sulfonamide; S. aureus DNA gyrase; SEM; Thiadiazino; Thiazolo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinoxalinas / Tiadiazinas / Girasa de ADN / Inhibidores de Topoisomerasa II / Antibacterianos / Antifúngicos Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article País de afiliación: Egipto

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