Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles.
J Am Chem Soc
; 142(20): 9460-9470, 2020 05 20.
Article
en En
| MEDLINE
| ID: mdl-32330031
ABSTRACT
The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiological processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.
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Banco de datos:
MEDLINE
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En
Revista:
J Am Chem Soc
Año:
2020
Tipo del documento:
Article
País de afiliación:
China