Negative charge of the AC-to-Hly linking segment modulates calcium-dependent membrane activities of Bordetella adenylate cyclase toxin.

Sukova, Anna; Bumba, Ladislav; Srb, Pavel; Veverka, Vaclav; Stanek, Ondrej; Holubova, Jana; Chmelik, Josef; Fiser, Radovan; Sebo, Peter; Masin, Jiri

Sukova, Anna; Bumba, Ladislav; Srb, Pavel; Veverka, Vaclav; Stanek, Ondrej; Holubova, Jana; Chmelik, Josef; Fiser, Radovan; Sebo, Peter; Masin, Jiri.

Afiliación

Sukova A; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Bumba L; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Srb P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti. 2, 166 10 Prague, Czech Republic.
Veverka V; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti. 2, 166 10 Prague, Czech Republic; Department of Cell Biology, Faculty of Science, Charles University, Vinicna 7, 128 00 Prague, Czech Republic.
Stanek O; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Holubova J; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Chmelik J; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Fiser R; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic; Department of Genetics and Microbiology, Faculty of Science, Charles University, Vinicna 5, 128 00 Prague, Czech Republic.
Sebo P; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
Masin J; Institute of Microbiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic. Electronic address: masin@biomed.cas.cz.

Biochim Biophys Acta Biomembr ; 1862(9): 183310, 2020 09 01.

Article en En | MEDLINE | ID: mdl-32333856

Asunto(s)

Toxina de Adenilato Ciclasa/química; Transporte Biológico/genética; Bordetella pertussis/química; Membrana Dobles de Lípidos/química; Toxina de Adenilato Ciclasa/metabolismo; Bordetella pertussis/metabolismo; Calcio/metabolismo; Membrana Celular/química; Membrana Celular/metabolismo; Permeabilidad de la Membrana Celular/genética; AMP Cíclico/metabolismo; Hemólisis/genética; Humanos; Membrana Dobles de Lípidos/metabolismo; Conformación Proteica en Hélice alfa/genética

Palabras clave

AC-to-Hly linking segment; Adenylate cyclase toxin; Calcium dependence; Membrane penetration; NMR structure

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transporte Biológico / Bordetella pertussis / Toxina de Adenilato Ciclasa / Membrana Dobles de Lípidos Límite: Humans Idioma: En Revista: Biochim Biophys Acta Biomembr Año: 2020 Tipo del documento: Article País de afiliación: República Checa

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