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Palliative electrochemotherapy in primary or recurrent vulvar cancer.
Corrado, Giacomo; Cutillo, Giuseppe; Fragomeni, Simona Maria; Bruno, Valentina; Tagliaferri, Luca; Mancini, Emanuela; Certelli, Camilla; Paris, Ida; Vizza, Enrico; Scambia, Giovanni; Garganese, Giorgia.
Afiliación
  • Corrado G; Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Cutillo G; Department of Experimental Clinical Oncology, Gynaecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
  • Fragomeni SM; Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Bruno V; Department of Experimental Clinical Oncology, Gynaecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy valentina.bruno@ifo.gov.it.
  • Tagliaferri L; Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia - Gemelli ART (Advanced Radiation Therapy), Interventional Oncology Center (IOC), Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Mancini E; Department of Experimental Clinical Oncology, Gynaecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
  • Certelli C; Department of Experimental Clinical Oncology, Gynaecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
  • Paris I; Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Vizza E; Department of Experimental Clinical Oncology, Gynaecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
  • Scambia G; Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Garganese G; Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Int J Gynecol Cancer ; 30(7): 927-931, 2020 07.
Article en En | MEDLINE | ID: mdl-32371425
OBJECTIVE: Since vulvar cancer is such a rare disease, the international experience with electrochemotherapy has been derived from only a few centers. The aim of this study was to evaluate clinical outcome and side effects profile with the use of electrochemotherapy in patients with primary or recurrent vulvar cancer. METHODS: Data were retrospectively collected from November 2017 to November 2019 in two major Italian oncologic institutes: Regina Elena Institute and Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Electrochemotherapy was offered in a palliative setting to patients with a primary or recurrent vulvar cancer who were not candidates for surgery or any other treatment, because of poor performance status or previous delivered treatments. All patients underwent general anesthesia. Electrical pulses were delivered using a pulse generator. Intravenous bleomycin was administered in conjunction with electrochemotherapy. Follow-up examinations were performed at 1, 3, and 6 months. Primary endpoint was to assess the response rate of electrochemotherapy as palliative treatment in patients with vulvar cancer. RESULTS: A total of 15 patients were included in the study. Fourteen patients (93.3%) had a squamous cell carcinoma and one patient had vulvar carcinosarcoma. Ten patients (66.7 %) had a single lesion and 5 patients (33.3%) had multiple lesions. Median number of electrical pulses was 22 (range 3-42) and median operative time was 13 (range 7-20) min. No intra-procedure complications occurred. One patient had pneumonia during their post-operative stay. Overall response rate after 1 month was 80%. At the 3-month follow-up, 3 patients (20%) had disease progression, 3 patients (20%) had died from ongoing disease, 1 patient (6.7%) died for other reasons, whereas the other patients maintained their 1-month clinical response. A total of 8/13 patients (61.5%) were alive at 6-month follow-up, whereas 6/12 patients (50%) were alive at 1-year follow-up. CONCLUSIONS: Electrochemotherapy is a feasible, easy to perform, and reproducible procedure in patients with primary or recurrent vulvar cancer who are unable to undergo surgery. Survival after 1 year in this population was 50%. Electrochemotherapy may have a role in the management of vulvar cancer, especially as palliative treatment when other therapies are no longer applicable.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vulva / Bleomicina / Electroquimioterapia / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Int J Gynecol Cancer Asunto de la revista: GINECOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vulva / Bleomicina / Electroquimioterapia / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Int J Gynecol Cancer Asunto de la revista: GINECOLOGIA / NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Italia