Single pulsed electromagnetic field restores bone mass and microarchitecture in denervation/disuse osteopenic mice.
Med Eng Phys
; 80: 52-59, 2020 06.
Article
en En
| MEDLINE
| ID: mdl-32376078
ABSTRACT
Pulsed electromagnetic fields (PEMFs) have been proposed to treat bone loss. However, time-consuming is the main complaint. A time-saving and effective treatment is of expectation. Previously, we showed a 3â¯min daily of single pulsed electromagnetic field (SPEMF) accelerated bone formation of long bone defect in mice. Here we compared the effect of SPEMF with PEMF for treating denervation/disuse osteopenic mice. Healthy mice were divided into 3 groups intact mice (INT), INTâ¯+â¯PEMF, and INTâ¯+â¯SPEMF. Induced osteopenic mice were divided to osteopenia (IOP), IOPâ¯+â¯PEMF, and IOPâ¯+â¯SPEMF groups. The PEMF treated groups were subjected to daily 8â¯h PEMF(15â¯Hz, 18â¯G) exposure, while SPEMF treated groups were daily 3â¯min SPEMF(0.2â¯Hz, 1 T) exposure. BMD was evaluated every two weeks during the 12 weeks of treatment. Microarchitecture was evaluated on week 12. SPEMF significantly reversed bone loss in IOP mice as early as 6 weeks post-treatment, while PEMF reversed bone loss after 8 weeks. Bone volume was significantly increased in the IOPâ¯+â¯PEMF and IOPâ¯+â¯SPEMF group. Besides, bone volume and trabecular number of IOPâ¯+â¯SPEMF mice were restored to the levels of INT mice in 12 weeks. Our finding suggests SPEMF increased BMD and restored microarchitecture of disuse osteopenic mice to healthy level.
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Banco de datos:
MEDLINE
Asunto principal:
Densidad Ósea
/
Campos Electromagnéticos
Límite:
Animals
Idioma:
En
Revista:
Med Eng Phys
Asunto de la revista:
BIOFISICA
/
ENGENHARIA BIOMEDICA
Año:
2020
Tipo del documento:
Article