Field cancerization: Definition, epidemiology, risk factors, and outcomes.
J Am Acad Dermatol
; 83(3): 709-717, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-32387665
ABSTRACT
Field cancerization was first described in 1953 when pathologic atypia was identified in clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated fields surrounding primary tumors raised the question of whether the development of subsequent tumors within the field represented recurrences or additional primary tumors. Since this initial study, field cancerization has been applied to numerous other epithelial tissues, including the skin. Cutaneous field cancerization occurs in areas exposed to chronic ultraviolet radiation, which leads to clonal proliferations of p53-mutated fields and is characterized by multifocal actinic keratoses, squamous cell carcinomas in situ, and cutaneous squamous cell carcinomas. In the first article in this continuing medical education series, we define field cancerization, review the available grading systems, and discuss the epidemiology, risk factors, and outcomes associated with this disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Neoplasias Cutáneas
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Neoplasias Primarias Secundarias
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Queratosis Actínica
/
Carcinogénesis
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Female
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Humans
/
Male
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2020
Tipo del documento:
Article